early life stress

SSRIs Add to the Existing Surplus of Serotonin in the Raphe Nucleus and Reduces Serotonin in Hippocampus, Where it Is Needed Most

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This appears to be the first good research showing why SSRIs do not work for most people in treating depression and anxiety. It appears that early life stress increases serotonin levels in the brain to the point that a negative feedback loop develops, reducing the brain’s sensitivity to the serotonin. The resulting depression and/or anxiety … Read more

Childhood Abuse and Neglect – The Objective Effects and the Subjective Experience

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The two articles below are complimentary in their description of the impact of childhood maltreatment (CM: abuse and/or neglect). The first is only available as an abstract (paywall, of course) and the second comes from Psych Central, a nice resource for lay readers in psychology. Together these articles show the impact of CM on the … Read more